MECHANISMS OF IMMEDIATE-EARLY GENES ACTIVATION

MECHANISMS OF IMMEDIATE-EARLY GENES ACTIVATION

Blog Article

In our article, we focus on molecular mechanisms of immediately early genes expression.We discuss extracellular signals that are transduced into the nucleus through a variety of signaling mechanisms to elicit changes in patterns of immediately early genes expression, chiefly focusing on c-fos.Immediate early genes are involved in many different normal and pathological processes including cell differentiation, cell proliferation, bekindtopets.com metabolism, inflammation, oncogenic transformation and stress.

The earliest known and best characterized include c-fos, c-myc and c-jun, genes that were found to be homologous to retroviral oncogenes.We highlight several signaling pathways that induce genes expression such as mitogen-activated protein kinase (MAPK), protein kinase A, protein kinase C, JAK-STAT and calcium-dependent pathways.Each one plays important role in immediate early genes activation.

Signal transduction eventually leads to the activation of transcription factors and epigenetic modifications.Immediate early gene products are on average mostly transcription factors.FOS and JUN are major components of the AP-1 transcription factor which is responsible for regulating late genes expression involved in multitude of different function such as cell icon track bar f250 proliferation and differentiation.

Therefore, abnormally immediate early gene expression contributes to pathological processes.